Introduction and Motivation

We would like BioClock to represent a platform for analysis of biological clock behaviour in living organisms. BioClock could analysis time-course microarray data to find probe sets (genes) behaviour in circadian mode. A circadian rhythm is a roughly 24-hour cycle in the biochemical, physiological, or behavioural processes of living entities (from Wikipedia). In addition, genes involved in circadian rhythm process from published microarray experiments were collected and stored in BioClock for users to browse.


BioClock System was supported by the poster below:

  • Daofeng Li, Rendong Yang, Zhenyan Miao, Tao Wang and Zhen Su, BioClock : a web server and database aimed for interpreting circadian rhythm 2010 ISMB (Poster). [Poster was also available at F1000 Poster Bank.]

BioClock currently support the following algorithms:

  1. Rendong Yang, Chen Zhang, Zhen Su, LSPR: an integrated periodicity detection algorithm for unevenly sampled temporal microarray data Bioinformatics. 2011; doi: 10.1093/bioinformatics/btr041. [Link]
  2. Rendong Yang and Zhen Su, Analyzing circadian expression data by harmonic regression based on autoregressive spectral estimation Bioinformatics. 2010 Jun 15;26(12):i168-74. [Link]


Fucntions of pages listed below:

  1. Home: this page. A brief introduction of this site:-)
  2. Analysis: analysis of time-cource microarray data, support file uploading.
  3. Browse: circadian data collection from published works.
  4. Jobs: check status of submitted analysis job.
  5. Search: search job quickly by job code generated when submitted analysis. (other functions are being developed.)
  6. Download: download our collection, support search by keyword.
  7. FAQ: frequently asked question -- a help file:-).